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| Name: | Jing Chen |
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| Position: |
Assistant Professor of Winship Cancer Institute |
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| Degree: |
Ph.D., Emory University, 2001 |
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| Programs: |
MSP,
Full Member BCDB, Full Member |
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| Phone: | 404 778-5274 | |
| Address: | 1365-C Clifton Rd, Rm 3002, 1751/001/1CD | |
| Email: | jchen@emory.edu | |
| Research Descriptions: | ||
| Short: | The pathogenic mechanism of human hematopoietic malignancies and solid tumors. | |
| Long: | Dr. Chen¿s research interest is centered on experiments designed for better understanding the pathogenic mechanism of human hematopoietic malignancies caused by dysregulated tyrosine kinases. His laboratory focuses on (1) the identification of signaling co-factors and effector proteins, as well as target genes in leukemogenic tyrosine kinase-induced hematopoietic transformation using proteomics and chip-based microarray assays; (2) characterization of the pathogenic roles of novel targets such as critical downstream signaling effectors in leukemogenic tyrosine kinase-transformed cell lines and animal disease models of leukemia, as well as primary malignant cells from human primary patient tissue samples; (3) development and validation of novel therapeutic strategies in preclinical translational studies, including application of novel peptidomimetic reagents that target protein-protein interactions to block transformation signal transduction by leukemogenic tyrosine kinases, sequence-specific siRNA and small molecule drugs that antagonize leukemogenic tyrosine kinases as well as downstream critical cofactors or signaling intermediates | |