Publications - Genetics & Molecular Biology at Emory University

Recent Publications of GMB Students

Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML, Moreno CS.
Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells. Cancer Res. 2009 Jan 15;69(2):709-17. PMID: 19147588

Coffee B, Ikeda M, Budimirovic DB, Hjelm LN, Kaufmann WE, Warren ST.
Mosaic FMR1 deletion causes fragile S syndrome and can lead to molecular misdiagnosis: a case report and review of the literature
Am J Med Genet A. 2008 May 15;146A(10):1358-67. Review. PMID: 18412117

Brykailo MA, McLane LM, Fridovich-Keil J, Corbett AH.
Analysis of a predicted nuclear localization signal: implication for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp 160. Nucleic Acids Res. 2007;35(20):6862-9. Epub 2007 Oct 11. PMID: 17933776

Bonawitz ND and Shadel GS.
Rethinking the Mitochondrial Theory of Aging: evidence for the role of mitochondrial gene expression in aging. Cell Cycle. 2007 Jul; 6(13):1574-1578.

Mills RE, Bennett EA, Iskow RC, Devine SE
Which transposable elements are active in the human genome?
Trends Genet. 2007 Apr;23(4):183-91. Epub 2007 Feb 27. Review. PMID: 17331616

Bonawitz ND, Chatenay-Lapointe M, Pan Y, and Shadel GS.
Reduced TOR signaling extends chronological lifespan in S. cerevisiae by increasing respiration via upregulation of mitochondrial gene expression. Cell Metab. 2007 Apr; 5(4):265-277. (Featured article for April 2007 and one of the 20 most downloaded papers from April 2007 to August 2007 at www.cellmetabolism.org

Brykailo MA, Corbett AH, Fridovich-Keil JL.
Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160. Nucleic Acids Res. 2007;35(4):1108-18. Epub 2007 Jan 30. PMID: 17264125 [ Bonawitz ND, Clayton DA, and Shadel GS.
Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Mol Cell. 2006 Dec; 24(6):813-825.

Bonawitz ND, Rodeheffer MS, and Shadel GS.
Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast lifespan. Mol Cell Biol. 2006 Jul; 26(13):4818-4829.

Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, and Shadel GS.
Novel roles for Ataxia-Telangectasia Mutated kinase in the regulation of ribonucleotide reductase and mitochondrial DNA homeostasis. J Clin Invest. (In press)

Cotney J, Wang Z, Shadel GS.
Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. Nucleic Acids Res. 2007;35(12):4042-54.

Wang Z, Cotney J, Shadel GS.
Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. J Biol Chem. 2007 Apr 27;282(17):12610-8.

Cotney J, Shadel GS.
Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. J Mol Evol. 2006 Nov;63(5):707-17.

Pezzementi L, Johnson K, Tsigelny I, Cotney J, Manning E, Barker A, Merritt S.
Amino acids defining the acyl pocket of an invertebrate cholinesterase. Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec;136(4):813-32.

Liu P, Ramachandran S, Ali Seyed M, Scharer CD, Laycock N, Dalton WB, Williams H, Karanam S, Datta MW, Jaye DL, Moreno CS.
Sex-determining region y box 4 is a transforming oncogene in human prostate cancer cells..
Cancer Res. 2006 Apr 15;66(8):4011-9

Norris BJ, Weaver AL, Morris LG, Wenning A, Garcia PA, Calabrese RL.
A central pattern generator producing alternative outputs: Temporal pattern of premotor activity.
J Neurophysiol. 2006 Apr 12; Epub ahead of print.

Mills RE, Bennett EA, Iskow RC, Luttig CT, Tsui C, Pittard WS, Devine SE. Am J Hum Genet.
Recently mobilized transposons in the human and chimpanzee genomes.
2006 Apr;78(4):671-9. Epub 2006 Feb 2.

Vrailas AD, Marenda DR, Cook SE, Powers MA, Lorenzen JA, Perkins LA, Moses K.
Smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye .
Development. 2006 Apr;133(8):1485-94. Epub 2006 Mar 15. PMID: 16540506. PubMed - in process

Wasilenko J, Fridovich-Keil JL.
Relationship between UDP-galactose 4'-epimerase activity and galactose sensitivity in yeast.
J Biol Chem. 2006 Mar 31;281(13):8443-9. Epub 2006 Feb 1. PMID: 16452467 PubMed - in process.

Danzy S, Su CY, Park S, Li SY, Ferraris AM, Ly H.
Absence of pathogenic mutations of the human telomerase RNA gene (hTERC) in patients with chronic myeloproliferative disorders.
Leukemia. 2006 Mar 2; Epub ahead of print.

Booker LM, Habermacher GM, Jessie BC, Sun QC, Baumann AK, Amin M, Lim SD, Fernandez-Golarz C, Lyles RH, Brown MD, Marshall FF, Petros JA.
North American white mitochondrial haplogroups in prostate and renal cancer.
J Urol. 2006 Feb;175(2):468-72; discussion 472-3.

Vrailas AD, Moses K.
Smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye .
Mech Dev. 2006 Feb;123(2):151-65. Epub 2006 Jan 18. PMID: 16412615. PubMed - in process.

Marenda DR, Vrailas AD, Rodrigues AB, Cook S, Powers MA, Lorenzen JA, Perkins LA, Moses K.
MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing.
Development. 2006 Jan;133(1):43-51. Epub 2005 Nov 24. PMID: 16308331 PubMed - in process.

Shin JY, Fang ZH, Yu ZX, Wang CE, Li SH, Li XJ .
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity.
J Cell Biol. 2005 Dec 19;171(6):1001-12. Erratum in: J Cell Biol. 2006 Mar 13;172(6):953. PMID: 16365166 PubMed - indexed for MEDLINE.

Rogers EM, Brennan CA, Mortimer NT, Cook S, Morris AR, Moses K .
Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow.
Development. 2005 Nov;132(21):4833-43. Epub 2005 Oct 5. PMID: 16207753 PubMed - indexed for MEDLINE.

Kumar S, Skeen MJ, Adiri Y, Yoon H, Vezys VD, Lukacher AE, Evavold BD, Ziegler HK, Boss JM. A cytokine promoter/yellow fluorescent protein reporter transgene serves as an early activation marker of lymphocyte subsets.
Cell Immunol. 2005 Oct;237(2):131-40. Epub 2006 Jan 10. PMID: 16405934 PubMed - indexed for MEDLINE. Mol Genet Metab. 2005 Jan;84(1):32-8. PMID: 15639193 PubMed - indexed for MEDLINE.

de Waal FB, Dindo M, Freeman CA, Hall MJ.
The monkey in the mirror: hardly a stranger .
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11137-9.

O'Rourke TW, Doudican NA, Zhang H, Eaton JS, Doetsch PW, Shadel GS.
Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability.
Gene. 2005 Jul 18;354:86-92.

Yoon HS, Ghaleb AM, Nandan MO, Hisamuddin IM, Dalton WB, Yang VW.
Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage.
Oncogene. 2005 Jun 9;24(25):4017-25. PMID: 15806166 PubMed - indexed for MEDLINE .

Lacreuse A, Diehl MM, Goh MY, Hall MJ, Volk AM, Chhabra RK, Herndon JG.
Sex differences in age-related motor slowing in the rhesus monkey: behavioral and neuroimaging data.
Neurobiol Aging. 2005 Apr;26(4):543-51.

Govindarajan B, Shah A, Cohen C, Arnold RS, Schechner J, Chung J, Mercurio AM, Alani R, Ryu B, Fan CY, Cuezva JM, Martinez M, Arbiser JL.
Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.
J Biol Chem. 2005 Apr 8;280(14):13936-43. Epub 2005 Feb 4. PMID: 15695519 PubMed - indexed for MEDLINE.

Kaur B, Khwaja FW, Severson EA, Matheny SL, Brat DJ, Van Meir EG.
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.
Neuro-oncol. 2005 Apr;7(2):134-53.

Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, Van Meir EG.
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Cancer Res. 2005 Jan 15;65(2):605-12. PMID: 15695405 PubMed - indexed for MEDLINE.

Wasilenko J, Lucas ME, Thoden JB, Holden HM, Fridovich-Keil JL .
Functional characterization of the K257R and G319E-hGALE alleles found in patients with ostensibly peripheral epimerase deficiency galactosemia.
Mol Genet Metab. 2005 Jan;84(1):32-8. PMID: 15639193 PubMed - indexed for MEDLINE .

Lacreuse A, Chhabra RK, Hall MJ, Herndon JG.
Executive function is less sensitive to estradiol than spatial memory: performance on an analog of the card sorting test in ovariectomized aged rhesus monkeys.
Behav Processes. 2004 Sep 30;67(2):313-9.

Li AM, Vargas CA, Brykailo MA, Openo KK, Corbett AH, Fridovich-Keil JL .
Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast.
Nucleic Acids Res. 2004 Sep 8;32(16):4768-75. Print 2004.

Villinger F, Miller R, Mori K, Mayne AE, Bostik P, Sundstrom JB, Sugimoto C, Ansari AA.
IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques .
Vaccine. 2004 Sep 3;22(25-26):3510-21. PMID: 15308379 PubMed - indexed for MEDLINE.

Muller EA, Danner DJ.
Tissue-specific translation of murine branched-chain a-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5' UTR.
J Biol Chem. 2004 Aug 9

Smith KT, Coffee B, Reines D.
Occupancy and synergistic activation of the FMR1 promoter by Nrf-1 and Sp1 in vivo.
Hum Mol Genet. 2004 Aug 1;13(15):1611-21. Epub 2004 Jun 02.

Gonzalez R, Smith CD, McClusky DA 3rd, Ramaswamy A, Branum GD, Hunter JG, Weber CJ .
Laparoscopic approach reduces likelihood of perioperative complications in patients undergoing adrenalectomy.
Am Surg. 2004 Aug;70(8):668-74.

Schulz JM, Watson AL, Sanders R, Ross KL, Thoden JB, Holden HM, Fridovich-Keil JL.
Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase.
J Biol Chem. 2004 Jul 30;279(31):32796-803. Epub 2004 Jun 02.

Salmon TB, Evert BA, Song B, Doetsch PW.
Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae.
Nucleic Acids Res. 2004 Jul 14;32(12):3712-23.

Evert BA, Salmon TB, Song B, Jingjing L, Siede W, Doetsch PW.
Spontaneous DNA damage in Saccharomyces cerevisiae elicits phenotypic properties similar to cancer cells.
J Biol Chem. 2004 May 21;279(21):22585-94.

Nandan MO, Yoon HS, Zhao W, Ouko LA, Chanchevalap S, Yang VW.
Kruppel-like factor 5 mediates the transforming activity of oncogenic H-Ras.
Oncogene. 2004 Apr 22;23(19):3404-13.

Kasinski A, Doering CB, Danner DJ.
Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism.
Brain Res Mol Brain Res. 2004 Mar 30;122(2):180-7.

Yedvobnick B, Kumar A, Chaudhury P, Opraseuth J, Mortimer N, Bhat KM.
Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.
Genetics. 2004 Mar;166(3):1281-9.

Yoon HS, Yang VW.
Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage.
J Biol Chem. 2004 Feb 6;279(6):5035-41. Epub 2003 Nov 19.

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