Rafi Ahmed, PhD

Immunology and pathogenesis of chronic viral infections; immunological memory and vaccine development.

John Altman, PhD

T-cell immune responses to HIV infection; vaccine development; development of T-cell memory.

Rama R. Amara, PhD

The goal of our laboratory is to develop novel therapeutic vaccines for HIV/AIDS, providing CD4 help for CD8 function.

Aftab Ansari, PhD

My lab effort is focused on studies of the cellular and molecular mechanisms of disease susceptibility and resistance in the SIV infected non-human primates.

Rustom Antia, PhD

Modeling the dynamics of immune responses and infections.

David Archer, PhD

Stem cell therapy for the treatment of inherited and acquired diseases.

Lawrence Boise, PhD

Basic mechanisms of apoptosis, and translation of these studies to better define the mechanism(s) of action therapeutic agents in multiple myeloma.

Jeremy Boss, PhD

Molecular immunology; regulation of major histocompatibility complex class II genes and tumor necrosis factor gene induction.

Richard Compans, PhD

Cell biology of virus replication, focusing on the membrane glycoproteins of enveloped RNA viruses.

Max Cooper, MD

My current research interests are normal and abnormal B cell biology and the evolution of adaptive immunity.

Richard D. Cummings, PhD

My current research interests are in the molecular mechanisms and roles of glycoconjugates, e.g. glycoproteins and glycolipids, in cell adhesion and cell signaling, development and disease, e.g. cancer and inflammation, and immunopathology as related to microbial and parasitic infections.

Cheryl Day, PhD

Cellular immunity and mechanisms of immune regulation in human Mycobacterium tuberculosis infection.

Timothy Denning, PhD

Mucosal immunology; intestinal macrophage and dendritic cell regulation of T cell differentiation and function.

Cynthia Derdeyn, PhD

Regions of the HIV-1 envelope glycoproteins that modulate HIV-1 transmission and pathogenesis in sub-Saharan Africa.

Brian Evavold, PhD

T-cell activation, antigen recognition; EAE autoimmunity model; role of SHP-1 phosphatase in T cell responses

Mandy Ford, PhD

Cellular mechanisms of induction and modulation of allospecific T cell responses

Mary Galinski, PhD

Discoveries of several P. vivax and P. falciparum merozoite vaccine candidates, basic studies of simian malaria models, and investigations of the molecular mechanisms that underpin antigen variation.

Jacques Galipeau, MD, FRCP(C)

Research and development of applied Immunology for the purpose of generating innovative biological and cell therapies for Immunotherapy of catastrophic ailments with unmet medical needs including cancer, alloimmune and autoimmune ailments.

Arash Grakoui, PhD

Our laboratory is committed to making significant contributions to the understanding of hepatitis C virus pathogenesis.

Eric Hunter, PhD

Elucidating the virus-cell interactions involved in the assembly and entry of retroviruses.

Neal Iwakoshi, PhD

Investigation of the cellular and molecular mechanisms of memory B cell and plasma cell differentiation.

Joshy Jacob, PhD

In situ analysis of B and T cell memory.

Daniel Kalman, PhD

Mechanisms by which enteropathogenic E. coli cause cytoskeletal and signaling changes in pathogenesis.

Jacqueline Katz, PhD

Influenza virus immunity and pathogenesis.

Allan D. Kirk, MD, PhD, FACS

My lab is interested in finding ways of controlling immune responses, particularly preventing organ transplant rejection without lifelong dependence on medication. We are primarily interested in the factors that initiate an immune response such as trauma and cellular stress, the cellular signals that amplify and sustain these responses, and ways of inhibiting these signals with fine precision.

Jacob Kohlmeier, PhD

Elucidating the mechanisms that regulate cellular immunity in the lung and translating these finding to combat respiratory pathogens..

Tracey Lamb, PhD

Generation of immune responses to malaria parasites; immunopathogenesis of malaria infections; development of a novel vaccine delivery system to vaccinate against malaria.

Patrick Lammie, PhD

T-cell responses to parasites, emphasis on filariasis and cryptosporidiosis.

Christian Larsen, MD, PhD

Understanding the fundamental mechanisms involved in T cell response to transplant tissues, and mechanisms involved in immunologic tolerance to self and transplanted tissues

Anice Lowen, PhD

My research focuses on two aspects of influenza virus biology: transmission of the virus from host-to-host and reassortment of the viral gene segments.

Janet M. McNicholl, MD

Molecular basis of T cell antigen recognition: applications to pathogenesis and vaccine research.

Jan Mead, PhD

Immune mechanisms and chemotherapy of parasitic diseases, with emphasis on C. parvum, Microsporidia and T. vaginalis.

Andrew Neish, MD

Current reseearch focuses on molecular events in prokaryotic-eukaryotic interactions.

Roberto Pacifici, MD

Mechanism of action of estrogen in bone; estrogen regulation of T cell function and osteoclast differentiation.

Mirko Paiardini, PhD

Comparative AIDS research in pathogenic and nonpathogenic HIV/SIV infections, with particular interest in the homeostasis of CD4+ T cell subsets with a key role in disease outcome. Regulation of mucosal immunity and Th17 cells in HIV/SIV infections.

Charles Parkos, MD, PhD

A major focus of the research in our laboratory is to better understand the pathophysiology of musosal inflammation that is broadly applicable to many inflammatory diseases.

Bali Pulendran, PhD

Dendritic cells, toll receptors, innate immunity and adaptive immune responses.

Jyothi Rengarajan, PhD

Host defense against microbial pathogens, host-pathogen interactions in tuberculosis

Paul Rota, PhD

Molecular basis for virulence of viruses which cause human disease; strategies to control pathogens.

Jeffrey Rumbaugh, MD, PhD

Dr. Rumbaugh’s research interests focus on exploring the molecular mechanisms of neurodegeneration in patients with HIV dementia and multiple sclerosis with the translational goal of developing neuroprotective therapies to target these pathways.

Periasamy Selvaraj, PhD

The main interest of our laboratory is biochemical and functional characterization of cell surface receptors involved in immune cell recognition and adhesion.

Guido Silvestri, MD

The pathogenesis of HIV infection and AIDS using the comparative non-human primate model of SIV infection in rhesus macaques and sooty mangabeys.

Paul Spearman, MD

The major focus of my laboratory is to understand the molecular and cellular basis for the assembly of HIV particles, and to develop particle-based HIV vaccines that can elicit effective neutralizing antibodies.

Samuel Speck, PhD

Pathogenesis of gamma-herpesviruses and development of lymphoma and other cancers.

John Steel, PhD

Development of influenza virus vaccines; elucidation of molecular determinants of influenza virus transmission

David Steinhauer, PhD

Functions of the influenza hemagglutinin in host cell entry; influenza assembly.

David S. Stephens, MD

Genetic basis and regulation of bacterial virulence components.

Malú Tansey, PhD

My lab studies the role and regulation of neuroinflammation and immune responses in CNS function with particular interest in neurodegenerative diseases.

Rabindra Tirouvanziam, PhD

The Tirouvanziam laboratory focuses on immunoinflammatory mechanisms involved in chronic diseases such as cystic fibrosis, allergy, and autism to improve our basic understanding of disease and identify new targets and endpoints for diagnostics, monitoring and therapy.

William Tyor, MD

Pathogenesis of viral infections and other inflammatory diseases of the central nervous system.

Edmund Waller, MD, PhD

Immune reconstitution after transplant. Allo-reactivity of memory vs naive T-cells. Regulation of immune polarization of T-cells by dendritic cells.

David S. Weiss, PhD

Host defense against bacterial pathogens and the molecular mechanisms of bacterial virulence.

Ifor Williams, MD, PhD

RANKL and intestinal M cell differentiation; novel mucosal vaccine strategies relying on M cells; lymphoid organogenesis in the intestine.

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