Population Biology of Infectious Disease

Within-host dynamics
Our research interests encompass a broad area of theoretical immunology and the interaction between pathogens and their hosts. I use mathematical models and computer simulations in conjunction with experimental data to:

• understand the dynamics of pathogens and immune responses in vivo,
• to estimate important biological parameters that are not directly measurable by experimentation,
• to generate empirical tests of different models and hypotheses.

Recent publications:

• Antia, R., Ganusov, V.V, & Ahmed, R. 2005 "The role of models in understanding CD8+ T cell memory." Nature Reviews Immunology. 5: 101-111.
• Bergstrom, C.T. & Antia, R. 2006. "How do adaptive immune systems control pathogens while avoiding autoimmunity?" Trends in Ecology and Evolution 21:22-28.
• Antia, R., Regoes, R.R., Koella, J.C., & Bergstrom, C.T. 2003. "The role of evolution in the emergence of infectious diseases." Nature 26:658-661.
• Handel, A., Regoes, R.R., & Antia, R. 2006. "Modeling compensatory mutations and the emergence of drug resistance." PloS Computational Biology. 2:e137.