Molecular Evolution & Evolutionary Genetics

Experimental Evolution
We study the role that the architecture of the genetic material has on its expression. More specifically we study the conservation of specific chromatin modifications and of the protein complexes responsible for these modifications.

Recent publications:

• Smith E.R., R. Huang, C. Cayrou, W. S. Lane, J. Cote, and J. C. Lucchesi 2005 "A human complex related to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16." Molec. Cell Biol., 25: 9175-9188.
• Lucchesi, J.C., Kelly, W.G., and B. Panning 2005 "Chromatin remodeling in dosage compensation." Annu. Rev. Genet., 39: 615-651.
• Yokoyama, R., Pannuti, A., Ling, H., Smith, E.R., and J.C. Lucchesi 2007 "A plasmid model system shows that Drosophila dosage compensation depends on the global acetylation of histone H4 at lysine 16 and is not affected by depletion of common transcription elongation chromatin marks." Mol. Cell. Biol. 27: 7865-7870.