Jordan Morreall wins 2014 11th Annual DSAC Student Research Symposium Oral Presentation Award

Jordan Morreall

Congratulations to Jordan Morreall, a Ph.D. Candidate in the Doetsch Laboratory, who was awarded 1st Place Oral Presentation for a talk he gave at the 11th Annual DSAC Student Research Symposium on January 10th 2014. Jordan's presentation entitled "TNF-a Inhibits DNA Repair Activity of BER Variant Ogg1 through Oxidative Stress" described his work on S326C-Ogg1, a common gene variant that is associated with a variety of cancers. The mechanism by which this gene variant leads to cancer is controversial, but the enzymatic activity of the variant is known to be inhibited by oxidative stress. They found that S326C-Ogg1 does not have an intrinsically different repair activity, but showed that its repair activity is inhibited by the physiological oxidative stressors H2O2 and TNF-a.