Blood-Based Biomarkers Could Enable Simple, Accurate TB Tests for Diagnosis and Monitoring
Researchers have identified blood-based biomarkers in patients with active tuberculosis (ATB) that could lead to new blood-based diagnostics and tools for monitoring treatment response and cure. The study was published online March 30 in the Journal of Clinical Investigation, led by Dr. Jyothi Rengarajan, faculty member in IMP and MMG.
Tuberculosis (TB) is a major global public health problem. In 2013 alone, there were an estimated nine million cases of ATB disease, and 1.5 million people died from TB.
“In order to reduce the burden of TB globally, identifying and treating all TB cases is a critical priority,” says Rengarajan. “However, accurate diagnosis of active TB disease remains challenging, and methods for monitoring how well a patient responds to the six-to nine-month long, four-drug regimen of anti-TB treatment, are highly inadequate."
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