Antibody-producing cells display 'historical record' of childhood infections

Immunologists from Emory University have identified a distinct set of long-lived antibody-producing cells in the human bone marrow that function as an immune archive.

The cells keep a catalog of how an adult's immune system responded to infections decades ago in childhood encounters with measles or mumps viruses. The results, published in Immunity, could provide vaccine designers with a goalpost when aiming for long-lasting antibody production.

IMP faculty members, Drs. Frances Eun-Hyung Lee and Ignacio Sanz, are co-senior authors of the paper.

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