NCI five-year grant extends nanoparticle research targeting pancreatic cancer
The National Cancer Institute (NCI) has awarded a five-year grant renewal to researchers at Winship Cancer Institute of Emory University who are developing nanoparticles to treat pancreatic cancer, one of the most deadly cancers.
The Innovative Research in Cancer Nanotechnology program project grant will support the research team to engineer theranostic magnetic iron oxide nanoparticles for use in nanotechnology enhanced targeted therapy and image guided drug delivery (thera – nostics).
The researchers' primary aim is to overcome a major barrier to treatment in pancreatic cancer – the stroma of pancreatic tumors. Stroma is the connective tissue that supports organs and provides nutrients and regulatory signals to cells, but tumor stroma becomes dense and fibrotic in pancreatic cancer, creating an obstacle to drug delivery and a micro-environment to support the aggressive nature of cancer cells.
One of the principal investigators for the $2.8 million grant is Lily Yang, MD, PhD, Emory professor of surgery and radiology; the Nancy Panoz Chair of Surgery in Cancer Research; and a faculty member in the CB and MSP programs. She is also a member of the Cancer Cell Biology Program at Winship.