Nox-ious link to cancer Warburg effect
At Emory, Kathy Griendling’s group is well known for studying NADPH oxidases (also known as Nox), enzymes which generate reactive oxygen species. In 2009, they published a paper on a regulator of Nox enzymes called Poldip2. Griendling’s former postdoc, now assistant professor, Alejandra San Martin has taken up Poldip2.
A recent PNAS paper from San Martin, Griendling and colleagues identifies Poldip2 as playing a role in hypoxia and cancer cell metabolic adaptation.
Both Drs. Griendling and San Martin are faculty members in the MSP program.